Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in mice.

The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal.

Intestinal resection resulting in short bowel syndrome (SBS) carries a heavy burden of long-term morbidity, mortality, and cost of care, which can be attenuated with strategies that improve intestinal adaptation. SBS infants fed human milk, compared with formula, have more rapid intestinal adaptation. We tested the hypothesis that the major noncaloric human milk oligosaccharide 2'-fucosyllactos...

Long-term parenteral nutritional support and intestinal adaptation in children with short bowel syndrome: a 25-year experience.

OBJECTIVE To analyze the outcome of children with short bowel syndrome (SBS) who required long-term parenteral nutrition (PN). STUDY DESIGN Retrospective analysis of children (n=78) with SBS who required PN >3 months from 1975 to 2000. STATISTICS univariate analysis, Kaplan-Meier method, and Cox proportional regression model were used. RESULTS We identified 78 patients. Survival was bette...

Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells

Intestinal stem cells (ISCs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. Lineage tracing experiments in mice have proven that ISCs can repopulate the entire intestinal crypt. It is noteworthy that in such experiments, only a subset of intestinal cr...

Comparison of Neonatal and Adult Mice-derived Sertoli Cells in Support of Expansion of Mouse Spermatogonial Stem Cells In vitro

Nutrition support of infants with short bowel syndrome.

Short bowel syndrome (SBS) is a clinically complex disorder resulting from alterations of normal intestinal anatomy and physiology and producing a variety of nutritional, infectious, and metabolic complications. It is usually defined functionally and is considered to be present when the patient has malabsorption in conjunction with a shortened small intestine.1 After resection, the residual sma...